Precancerous lesions breast

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These lesions are premalignant and associated with an increased risk of subsequent breast carcinoma in both the ipsilateral and contralateral breast. However, they are inconsistently treated in spite of effective chemoprevention strategies. Here, we review the pertinent pathological features, cumulative risk, and risk modifiers for subsequent invasive breast carcinoma, as well as clinical management of patients with these atypical lesions.

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Hi, I was told a week ago that I have pre cancerous cells in my right breast and need to have a mastectomy. Right now, I'm wondering if having pre cancerous cells in one part of the body means there may be more elsewhere? I'm struggling to believe that I'll simply have the breast removed and reconstructed and that's that if you know what I mean?

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A precancerous condition is a condition or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. Some of the most common precancerous conditions include certain colon polypswhich can progress into colon cancermonoclonal gammopathy of undetermined significancewhich can progress into multiple myeloma or myelodysplastic syndrome. Sometimes the term "precancer" is also used for carcinoma in situwhich is a noninvasive cancer that has not progressed to an aggressive, invasive stage.

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EllisAndrew M. HanbyEdiz F. CosarEmad A.

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Breast cancer, the product of numerous rare mutational events that occur over an extended time period, presents numerous challenges to investigators interested in studying the transformation from normal breast epithelium to malignancy using traditional laboratory methods, particularly with respect to characterizing transitional and pre-malignant states. Dynamic computational modeling can provide insight into these pathophysiological dynamics, and as such we use a previously validated agent-based computational model of the mammary epithelium the DEABM to investigate the probabilistic mechanisms by which normal populations of ductal cells could transform into states replicating features of both pre-malignant breast lesions and a diverse set of breast cancer subtypes. The DEABM consists of simulated cellular populations governed by algorithms based on accepted and previously published cellular mechanisms.

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Background: Unanimously recognized precancerous breast lesions are atypical ductal hyperplasia ADHatypical lobular hyperplasia, flat epithelial atypia, lobular carcinoma in situpapillary lesions, and proliferative radial scar. The increased risk of developing carcinoma associated with these lesions is found for both ipsi- and contra-lateral breasts. These precancerous lesions are also found in benign breast lesions.

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The term high-risk breast lesion is given to a breast lesion that carries an increased risk for the future development of breast cancer or carries suspicion of a more sinister pathology around or in association with the lesion. The term has some overlap with borderline breast disease. Many radiologists recommend excision of these lesions when they are revealed on pathological analysis after a core biopsy.

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Changes seen in cells of the lobules suggest that cancer could occur in the future. Both breasts are at elevated cancer risk when LCIS is discovered even on only one side. These patients, Hudis and other specialists say, must be monitored closely.

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